Filming began in June 2006 in Vancouver and Edmonton, with some scenes shot in Los Angeles. Good Luck Chuck opened in theaters on September 21, 2007 and was heavily panned by critics.

While playing a game seven minutes in heaven at a party in 1985, ten-year-old Chuck (Connor Price) refuses to makeout with a gothic girl named Anisha (Sasha Pieterse). In retaliation, Anisha, who possesses witchcraft, places a curse on Chuck: "every single woman he sleeps with will break up with him and marry the next guy who asks her out".

In the present, Chuck (Dane Cook) is now in his thirties and runs a dentist practice in the same building as his best friend Stu's (Dan Fogler) plastic surgery business. Chuck finds himself unable to tell his girlfriend Carol (Chelan Simmons) that he loves her and she breaks up with him while having sex on the beach. At a wedding, Chuck becomes enamored with Cam Wexler (Jessica Alba), a sometimes clumsy, but friendly girl. Chuck asks Cam for a date, but she gently refuses him.

While working at a penguin habitat, Cam accidentally slips and breaks her tooth. When she visits Chuck to have it fixed, he asks her to go out with him instead of paying him. Though initially reluctant, Cam agrees. Meanwhile, Stu notices the pattern of girls getting married as soon as Chuck has sex with them. Stu eventually convinces Chuck to embrace the influx of women who have learned of his pattern and visit his practice, arguing that there's nothing better than having lots of guilt-free sex. However, after having this so called "guilt-free sex" with a bunch of women, Chuck wants to stop and have a serious relationship with Cam. However, just before he has sex with her, Stu informs him that each of the women Chuck has slept with has gotten married, including Carol. Worried that the same thing will happen to Cam, Chuck begins to avoid her.

Stu convinces Chuck to test the curse by having sex with a fat and ugly woman to see if she'll get married afterward. Chuck asks Stu to get the woman out to see if they get married, but Stu only pretends to do so. Chuck, believing the curse is fake, has sex with Cam. Afterward, Stu confesses, the woman gets married to another man, and Chuck believes Cam wants to go out with the author of a book about penguins, who she has raved about. Chuck attempts to track down the girl who placed the curse on him when they were kids. Now a happily married woman with a child, the former goth girl tells Chuck that the curse wasn't meant to be real. Still convinced that Cam will date and eventually marry the book author, Chuck tries desperately to get Cam's attention and ask her to marry him. His attempts, though, cause Cam to become convinced he's stalking her and she breaks up with him.

Now deciding to let fate take its course, Chuck puts Cam in touch with the book author, and the two seem to connect instantly. Stu convinces Chuck to chase after Cam, who is now headed to Antarctica with the book author. After Chuck finds her, Cam reveals that the book author is already married to someone else, and that she's only leaving for a week. Chuck hands Cam a ring box containing a pebble, a reference to the penguin mating ritual in which a male penguin finds a stone and brings it to the female penguin he wants to be with. Anisha is shown pulling a pin out of a voodoo doll, and the curse is finally broken. A year later, Chuck and Cam are in Antarctica together surrounded by penguins. As they kiss, their tongues get frozen together while they laugh at each other.

Filmed on location in Canada (Vancouver; British Columbia and Edmonton; Alberta)

According to Rotten Tomatoes, only 4% of critics gave the film positive reviews, based on 110 reviews. On Metacritic, the film had an average score of 19 out of 100, based on 21 reviews, indicating "extreme dislike or disgust".

Roger Ebert awarded the film 1 out of 4 stars, branding it "potty-mouthed and brain-damaged", whilst his reviewing partner, Richard Roeper, gave an equally damning review, saying that "There is a scene in this movie where a penguin bites Dane Cook in the crotch. I'd like to find that penguin and buy it a drink."

The film was the second-highest grossing film at the U.S. box office in its opening weekend, grossing $13.6 million in 2,612 theaters. The film went on to have a total box office tally of approximately $35 million U.S. and $24 million foreign.